|
KMID : 0359920060250050737
|
|
Korean Journal of Nephrology
2006 Volume.25 No. 5 p.737 ~ p.744
|
|
|
Serum Cystatin C Concentration Compared with Serum Creatinine Concentration as a Marker of Glomerular Filtration Rate
|
|
Han Kum-Hyun
Han Sang-Youb
Kang Young-Sun
Cha Dae-Ryong
|
|
|
Abstract
|
|
|
Background : Several studies have shown serum cystatin C to be a better parameter for glomerular filtration rate (GFR) than serum creatinine (sCr). It is also known to be more sensitive in detecting of early renal impairment.
Methods : Serum samples were obtained from 518 subjects with various renal functions for GFR determination and cystatin C measurement. GFRs were estimated by Modification of Diet in Renal Disease (MDRD) formula and classified 5 stages according to KDOQI CKD classification. The relationships between the levels of serum cystatin C or sCr and the stages of GFR were determined.
Results : The mean levels of serum cystatin C in stage 1 (normal renal function) subjects were not different in stage 2 (mild renal impairment) subjects (0.9±0.3 vs. 0.9±0.3 (mg/L), p>0.05). The mean levels of sCr in stage 1 subjects also were not different from the ones in stage 2 subjects (0.7±0.1 vs. 1.0±0.2 (mg/dL), p>0.05). The levels of cystatin C in stage 3 (moderate renal impairment) were significantly higher than those in stage 2 subjects. The difference of serum levels of cystatin C between stage 2 and stage 3 was more significant than the difference of sCr (0.9±0.3 vs. 1.2±0.6, p=0.007: 1.0± 0.2 vs. 1.3±0.3, p=0.02). The levels of cystatin C and sCr were increased as GFR decreased after stage 2. The correlation of cystatin C with GFR was similar to that of sCr (-0.675 vs. -0.670)
Conclusion : Serum cystatin C is not better than sCr for detecting of early renal impairment, but, gives a good assessment of GFR change during the follow-up. (Korean J Nephrol 2006;25(5):737-744)
|
|
|
KEYWORD
|
|
|
Cystatin C, Creatinine, GFR
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|